ABSTRACT
Many epidemiological studies were conducted for studying Lyme borreliosis [LB] which represents a new global public health problem. It is now the most common vector-borne disease in Europe and North America. The causative agent Borrelia burgdorferi sl is a bacterial species complex comprising 12 delineated and named species. In North Africa, few studies based on clinical and serological features, have suggested that LB could occur. Indeed, recent studies conducted in Tunisia, Algeria and Morocco have shown that Ixodes ricinus is present in cooler and humid area of these regions. These studies also revealed that this species is a vector of B. burgdorferi sl with high prevalence of infection. Using IFI and PCR tests, the mean rate of Borrelia infection ranged from 50 to 60 % in I. ricinus adult collected in Tunisia and Morocco and from 30 to 40% in nymphs; in contrast, the prevalence in larvae is less than 2.5 %. Several strains of B. burgdorferi were isolated from adult and nymph I. ricinus collected in Tunisia and Morocco. The identification of these strains and DNAs directly extracted from Ixodes was done by PCRRFLP and sequence analysis. The results showed that B.lusitaniae [genotypes Poti B2 and Poti B3] is the predominant species circulating in I. ricinus in Tunisia and Morocco, B. garinii and B. burgdorferi ss and B lusitaniae were also present but very rare. These results provide the evidence for the existence of B. burgdorferi sl in North Africa; however, the impact of LB in the human population seem to be negligible and the seroprevalence of Borrelia in forest workers [considered as population at high risk] in Tunisia is less than 4%
ABSTRACT
The authors report a first Tunisian case of arginino-succinic acidura of a new-born from a consanguin parents admitted in secondf day of life with neurologic distress. The diagnosis oriented by the clinical patterns and the familial history has been confirmed by the amino-acid chromatography. The case presented is characterised by a fatal cardiac failure that has been associated with a classical neurologic distress